Not only does it take time to get an accurate depression diagnosis, finding the right medication to treat depression can be a complicated, delicate process. Someone may have a serious medical problem, such as heart disease or liver or kidney disease, that could make some antidepressants unsafe. The antidepressant could be ineffective for you or the dose inadequate; there may not have been enough time to see an effect, or the side effects could be too bothersome -- leading to a failure of treatment.
Ketamine is generally safe and has few side effects — besides that dissociative “high” thing, which can distress some people. Researchers still don’t know how well it works, exactly what the dose should be, and how long people ought to be treated with it. Like other antidepressants, how it works isn’t entirely clear either — it has effects on many chemical of our body’s signaling systems. But because it might only take a few treatments over a few weeks to see the same kinds of results that people see with today’s antidepressant pills — and faster — it’s a treatment that might help a lot of people.
Talk therapy involves discussing your problems and how you feel with a trained therapist. Your therapist can help you detect patterns of thought or behavior that contribute to your depression. You may be given homework, such as tracking your moods or writing in journals. This will help you to continue your treatment outside of appointments. Your therapist can also teach you exercises to reduce stress and anxiety, and help you understand your illness.