Phobias are extreme and irrational fears about a particular thing. The can be so great that the person goes to great lengths to avoid it, even if it’s harmless. For example social phobia is fear of being judged or embarrassed in public, even in everyday situations like when eating, speaking at work or making small talk.  Another type is agoraphobia, often thought to be a fear of open spaces. It is also a fear of being closed in, or away from a safe place or person who makes you feel safe. It can be extremely disabling and frightening, and can leave people unable to leave their home.
Very often, a combination of genetic, psychological, and environmental factors is involved in the onset of a depressive disorder. Stressors that contribute to the development of depression sometimes affect some groups more than others. For example, minority groups who more often feel impacted by discrimination are disproportionately represented. Socioeconomically disadvantaged groups have higher rates of depression compared to their advantaged counterparts. Immigrants to the United States may be more vulnerable to developing depression, particularly when isolated by language.
Patience is required because the treatment of depression takes time. Sometimes, the doctor will need to try a variety of antidepressants before finding the medication or combination of medications that is most effective for the patient. Sometimes, it's necessary to increase the dosage to be effective or decrease the dosage to alleviate medication side effects.

There is no single known cause of depression. Rather, it likely results from a combination of genetic, biologic, environmental, and psychological factors. Major negative experiences—trauma, loss of a loved one, a difficult relationship, or any stressful situation that overwhelms the ability to cope—may trigger a depressive episode. Subsequent depressive episodes may occur with or without an obvious trigger. Depression is not an inherent consequence of negative life events; research increasingly suggests that it is only when such events set in motion excessive rumination and negative thought patterns, especially about oneself, that mood enters a downward spiral.
Sadness can be a difficult emotion to deal with, not only due to the pain it causes, but also because of the factors that caused the sadness in the first place. Sadness can be the result of loss, helplessness, or disappointment, among many other things. It is important to remember, though, that sadness is one of the most common and natural human emotions, and is something that will ultimately help us appreciate our happy times.
Sadness can be a difficult emotion to deal with, not only due to the pain it causes, but also because of the factors that caused the sadness in the first place. Sadness can be the result of loss, helplessness, or disappointment, among many other things. It is important to remember, though, that sadness is one of the most common and natural human emotions, and is something that will ultimately help us appreciate our happy times.

High-functioning anxiety and depression is treated the same way as other anxiety and depressive disorders, through psychotherapy and medication. Cognitive behavioral therapy (CBT) combined with antidepressants or antianxiety medications can be very effective and shows improved outcomes over treatment that employs only therapy or medication. Residential treatment can also be beneficial for people living with high-functioning anxiety and depression. Residential treatment allows for individuals to get care in a home-like setting, but in a controlled environment away from home, possible triggers, and the rigors of daily life.


There are various methods you could use to sooth the symptoms of depression. All of us could stand to exercise more often, but exercise is especially helpful for the depressed mind. It enables you to better handle stress, and the endorphins released during exercise give you a mental boost. Aside from the mental health benefits, the Centers for Disease Control and Prevention (CDC) report that physical activity helps you sleep better at night.
Adoration Aesthetic emotions Affection Agitation Agony Amusement Anger Anguish Annoyance Anxiety Apathy Arousal Attraction Awe Boredom Calmness Compassion Contempt Contentment Defeat Depression Desire Disappointment Disgust Ecstasy Embarrassment Vicarious Empathy Enthrallment Enthusiasm Envy Euphoria Excitement Fear Flow (psychology) Frustration Gratitude Grief Guilt Happiness Hatred Hiraeth Homesickness Hope Horror Hostility Humiliation Hygge Hysteria Infatuation Insecurity Insult Interest Irritation Isolation Jealousy Joy Limerence Loneliness Longing Love Lust Melancholy Mono no aware Neglect Nostalgia Panic Passion Pity Pleasure Pride hubris Rage Regret Rejection Remorse Resentment Sadness Saudade Schadenfreude Sehnsucht Sentimentality Shame Shock Shyness Sorrow Spite Stress Suffering Surprise Sympathy Tenseness Wonder Worry
The causes of SAD are unclear, says NIMH, but research suggests it may be due to seasonal fluctuations in levels of serotonin, a brain chemical that helps regulate mood, or to an overproduction of melatonin, the hormone that regulates sleep. Scientists also posit that people with SAD may produce too little vitamin D, which impacts serotonin activity.
Another brain stimulation therapy, transcranial magnetic stimulation (TMS) involves a physician passing an electrical current through an insulated coil that is placed on the surface of the depression sufferer's scalp. That induces a brief magnetic field that can change the electrical flow of the brain that is effective in easing symptoms of depression or anxiety. TMS does not require anesthesia; doctors perform TMS for a few minutes per session, five times per week over the course of four to six weeks. Side effects are usually mild and fade quickly, including scalp discomfort or headaches. It is unusual for side effects to be severe enough to cause the recipient to stop treatment prematurely. Serious side effects are rare, including worsened depression, suicidal thoughts, or actions.
While this newly approved treatment offers hope as a fast acting and durable antidepressant option for patients who have not responded adequately to conventional SSRI or SNRI medications, it is important to be cautious. Many patients may seek out esketamine have not received trials with other evidence-based treatments including pharmacotherapy and psychotherapy or rTMS or ECT. 

The definition of a genetic disease is a disorder or condition caused by abnormalities in a person's genome. Some types of genetic inheritance include single inheritance, including cystic fibrosis, sickle cell anemia, Marfan syndrome, and hemochromatosis. Other types of genetic diseases include multifactorial inheritance. Still other types of genetic diseases include chromosome abnormalities (for example, Turner syndrome, and Klinefelter syndrome), and mitochondrial inheritance (for example, epilepsy and dementia).
The causes of SAD are unclear, says NIMH, but research suggests it may be due to seasonal fluctuations in levels of serotonin, a brain chemical that helps regulate mood, or to an overproduction of melatonin, the hormone that regulates sleep. Scientists also posit that people with SAD may produce too little vitamin D, which impacts serotonin activity.

Tricyclic antidepressants (TCAs) were some of the first medications used to treat depression. Examples are amitriptyline (Elavil), desipramine (Norpramin, Pertofrane), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Side effects include stomach upset, dizziness, dry mouth, changes in blood pressure, changes in blood sugar levels, and nausea.


Although no one knows exactly why, depression and anxiety often occur together. In one study, 85% of those with major depression were also diagnosed with generalized anxiety disorder and 35% had symptoms of panic disorder. Other anxiety disorders include obsessive-compulsive disorder and post-traumatic stress disorder (PTSD). Because they so often go hand in hand, anxiety and depression are considered the fraternal twins of mood disorders.

Dr. Roxanne Dryden-Edwards is an adult, child, and adolescent psychiatrist. She is a former Chair of the Committee on Developmental Disabilities for the American Psychiatric Association, Assistant Professor of Psychiatry at Johns Hopkins Hospital in Baltimore, Maryland, and Medical Director of the National Center for Children and Families in Bethesda, Maryland.


The ADAA 2020 40th Annual Conference (March 19-22, San Antonio, Texas) will bring together clinicians and researchers who want to improve treatments and find cures for anxiety, depression and related disorders. Join more than 1,400 peers from across the US and around the world. Connect, share and collaborate. Choose from 160+ sessions, hear engaging keynotes, learn about cutting-edge thinking in research and clinical practice, and earn continuing education credits (CEs and CMEs). Find your professional home and leave more connected to your peers, and better able to integrate research, practice, and community. #ADAA2020
Patients generally tolerate SSRIs well, and side effects are usually mild. The most common side effects are nausea and other stomach upset, diarrhea, agitation, insomnia, and headache. However, these side effects generally go away within the first month of SSRI use. Some patients experience sexual side effects, such as decreased sexual desire (decreased libido), delayed orgasm, or an inability to have an orgasm. Sexual side effects occur less often with newer SSRIs like vortioxetine and vilazodone, compared to the older medications in this category. For those patients, especially for whom anxiety is a prominent symptom of depression, the addition of buspirone may help enhance the effectiveness (augment) the effect of the SSRI while decreasing or eliminating sexual side effects. Uncommonly, some patients experience tremors, hair loss, or gradual weight gain with SSRIs. The so-called serotonergic (meaning caused by serotonin) syndrome is a serious neurologic condition associated with the use of SSRIs, usually when given in high doses or in combination with another SSRI. High fevers, seizures, and heart-rhythm disturbances characterize serotonergic syndrome. This condition is very rare and tends to occur only in very ill psychiatric patients taking multiple psychiatric medications.
Cognitive behavioral therapy. Pain is demoralizing as well as hurtful. Cognitive behavioral therapy (CBT) is not only an established treatment for anxiety and depression, it is also the best studied psychotherapy for treating pain. CBT is based on the premise that thoughts, feelings, and sensations are all related. Therapists use CBT to help patients learn coping skills so that they can manage, rather than be victimized by, their pain.

All antidepressants on the market are potentially effective. [120] Usually, 2–6 weeks at a therapeutic-dose level are needed to observe a clinical response. The choice of medication should be guided by anticipated safety and tolerability, which aid in compliance; physician familiarity, which aids in patient education and anticipation of adverse effects; and history of previous treatments. Often, treatment failures are caused not by clinical resistance but by medication noncompliance, inadequate duration of therapy, or inadequate dosing.
Anxiety and depression are the most common mental health disorders. In the U.S., approximately 19 million people suffer from anxiety and 18 million from depression. Additionally, it is estimated that about 85 percent of Americans with depression also suffer from an anxiety disorder, and almost 54 percent of people with an anxiety disorder also have major depression.
A very small number of people have had heart problems, epileptic fits or liver damage while taking antidepressants. It is believed that these were rare side effects of antidepressants. Various studies suggest that teenagers consider suicide more often when taking SSRIs or SSNRIs and also actually attempt to take their own lives more often. Teenagers should see their doctor or therapist more regularly at the beginning of treatment so that any risk of suicide can be identified early on.
Depression is different from anxiety. Rather than feeling anxious and nervous, feelings of gloom and melancholy overwhelm. Feeling sad or down after experiencing a loss or disappointment is an emotion that everyone feels at one time or another. But when low mood and sadness is severe and lasts for long periods of time, it could be due to depression.

Develop good habits. Take your depression medicine at the same time every day. It's easier to remember if you do it along with another activity such as eating breakfast or getting into bed. Get a weekly pillbox, which will make it easy to see if you've missed a dose. Since people sometimes forget a dose now and then, make sure you know what to do if that happens.


Multiple sclerosis (MS) symptoms vary from person to person, and can last for days to months without periods of remission. Symptoms of MS include sexual problems and problems with the bowel, bladder, eyes, muscles, speech, swallowing, brain, and nervous system. The early symptoms and signs of multiple sclerosis usually start between age 20 and 40. MS in children, teens, and those over age 40 is rare. Treatment options for multiple sclerosis vary depending on the type and severity of symptoms. Medications may be prescribed to manage MS symptoms.
Although no one knows exactly why, depression and anxiety often occur together. In one study, 85% of those with major depression were also diagnosed with generalized anxiety disorder and 35% had symptoms of panic disorder. Other anxiety disorders include obsessive-compulsive disorder and post-traumatic stress disorder (PTSD). Because they so often go hand in hand, anxiety and depression are considered the fraternal twins of mood disorders.

Bipolar disorder is different from depression, but it is included in this list is because someone with bipolar disorder experiences episodes of extremely low moods that meet the criteria for major depression (called “bipolar depression”). But a person with bipolar disorder also experiences extreme high – euphoric or irritable – moods called “mania” or a less severe form called “hypomania.”
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