Beware of drug interactions. You should avoid drinking alcohol when taking SSRIs since it can lessen the effects of the medication. Dangerous drug interactions can occur when SSRIs are taken with antihistamines, found in many over-the-counter cold and allergy medicines and sleep aids, or with prescription painkillers. Always talk to your doctor or pharmacist before combining medications.
About Depression:  Feelings of depression may be described as feeling sad, blue, unhappy, miserable, or down in the dumps. Most of us feel this way at one time or another for short periods. But true clinical depression is a mood disorder in which feelings of sadness, loss, anger, or frustration interfere with everyday life for an extended period of time.

Symptoms of depression and anxiety are most common among people with chronic migraine, which is when headache attacks occur on 15 or more days a month. For people with fewer headaches, depression or anxiety puts them at risk for more headaches over time. Symptoms of depression and anxiety also impact other areas of health. Migraine patients with depression or anxiety have higher medical costs, are at increased risk for suicide, and have higher levels of disability than migraine patients without depression or anxiety. Also, and perhaps most importantly, headache treatments don’t work as well when the depression or anxiety is not also being treated. Untreated patients are less likely to follow medicine or behavior treatment plans. They also show less response to headache medications, and are more likely to relapse. For these reasons, treating all these conditions is very important.

When you’re depressed, just getting out of bed can seem like a daunting task, let alone working out! But exercise is a powerful depression fighter—and one of the most important tools in your recovery arsenal. Research shows that regular exercise can be as effective as medication for relieving depression symptoms. It also helps prevent relapse once you’re well.

Depressive disorders can make those afflicted feel exhausted, worthless, helpless, and hopeless. Such negative thoughts and feelings make some people feel like giving up. It is important to realize that these negative views are part of the depressive illness and typically do not accurately reflect the actual situation. Negative thinking fades as treatment begins to take effect. In the meantime, the following are helpful tips for how to fight depression:
Patients often are tempted to stop their medication too soon, especially when they begin feeling better. It is important to keep taking medication therapy until the doctor says to stop, even if the patient feels better beforehand. Doctors often will continue the antidepressant medications for at least six to 12 months after symptoms are alleviated because the risk of depression quickly returning when treatment is stopped decreases after that period of time in those people experiencing their first depressive episode. Patients must stop some medications gradually to give the body time to adjust (see discontinuation of antidepressants below). For individuals with bipolar disorder, recurrent or chronic major depression, medication may have to become a part of everyday life for an extended period of years in order to avoid disabling symptoms.

Depression can increase the risks for developing coronary artery disease and asthma, contracting the human immunodeficiency virus (HIV) and many other medical illnesses. Other complications of depression include its tendency to increase the morbidity (illness/negative health effects) and mortality (death) from these and many other medical conditions.
Monoamine oxidase inhibitors or MAOIs were the first class of antidepressants to be developed. They fell out of favor because of concerns about interactions with certain foods and numerous drug interactions. MAOIs elevate the levels of norepinephrine, serotonin, and dopamine by inhibiting an enzyme called monoamine oxidase. Monoamine oxidase breaks down norepinephrine, serotonin, and dopamine. When monoamine oxidase is inhibited, norepinephrine, serotonin, and dopamine are not broken down, increasing the concentration of all three neurotransmitters in the brain.
Over the years, the technique of ECT has improved from the procedure that still invokes stigma in the minds of many. Physicians administer the treatment in the hospital under anesthesia so that people receiving ECT do not hurt themselves or feel emotional or physical pain during the induced seizures or at any other time. Most patients undergo six to 10 treatments. A health care professional passes an electrical current through the brain to cause a controlled seizure, which typically lasts for 20-90 seconds. The patient is awake in five to 10 minutes. The most common side effect is short-term memory loss, which usually resolves quickly. Doctors safely perform ECT as an outpatient procedure.
People who are depressed will usually show a style of thinking that focuses on negative views of the world. They often think of themselves as worthless and of the world as being a bad or unfair place, and they are without hope that their lives will improve in the future. When something bad happens, they blame themselves, but when good things happen, they tell themselves they are just lucky. Furthermore, people with depression are less likely to recognize and appreciate positive events when they happen; rather, they tend to be more tuned into the bad things in their lives and brood over those events.
Stressful life events play a part in the onset or relapse of depression. Ongoing conflicts with others can take their toll on our well-being, as can other social and environmental stressors such as financial difficulties, retirement, unemployment, childbirth, loneliness, or loss of someone or something important. In vulnerable people, these unpleasant life events may be enough to cause or worsen a depressive illness.
There are various methods you could use to sooth the symptoms of depression. All of us could stand to exercise more often, but exercise is especially helpful for the depressed mind. It enables you to better handle stress, and the endorphins released during exercise give you a mental boost. Aside from the mental health benefits, the Centers for Disease Control and Prevention (CDC) report that physical activity helps you sleep better at night.
Many factors contribute to depression, and it is likely caused by an imbalance of brain chemicals. Life events (such as stressful life changes) may also contribute to a depressed mood. Depression also tends to run in families. The exact biological cause of depression is still being investigated, including by scientists at McLean like Diego A. Pizzagalli, PhD.

Selective serotonin reuptake inhibitors (SSRIs). Doctors often start by prescribing an SSRI. These medications generally cause fewer bothersome side effects and are less likely to cause problems at higher therapeutic doses than other types of antidepressants are. SSRIs include fluoxetine (Prozac), paroxetine (Paxil, Pexeva), sertraline (Zoloft), citalopram (Celexa) and escitalopram (Lexapro).

The SSRI antidepressants can cause sexual dysfunction. SSRIs reportedly decrease sex drive (libido) in both men and women. SSRIs reportedly cause inability to achieve orgasm or delay in achieving orgasm (anorgasmia) in women and difficulty with ejaculation (delay in ejaculating or loss of ability to ejaculate) and erections in men. Sexual dysfunction with SSRIs is common though the exact incidence is unknown. Newer SSRIs like vortioxetine and vilazodone have little to no negative impact on sexual functioning. Furthermore, patients have reported sexual side effects with the use of other antidepressant classes such a MAOIs, TCAs, and dual-action antidepressants.

Older adults—Around 7% of seniors have some symptoms of depression. This can be brought on by the loss of a spouse, a shrinking circle of friends or the onset of an illness. It’s also much more common among seniors living in care homes or who have dementia. Depression in people 65 and over appears to be less common than in younger groups, but researchers aren’t sure if this is a real difference or an issue with the research questions. It’s likely that depression is at least somewhat under-recognized in seniors. Some symptoms like changes in sleep or activity levels may be mistaken as signs of aging instead of depression.


People get confused about the distinction between anxiety and depression for several reasons. The first is that, if they are receiving medication for an anxiety disorder, they're probably getting an anti-depressant medication. A group of anti-depressant medications known as the Selective Serotonin Reuptake Inhibitors (SSRI) have been demonstrated to be helpful with both anxiety and depression, and are now the preferred medication treatment for people who receive medication for anxiety disorders. Sometimes people with anxiety disorders receive these medications, find out they're taking an anti-depressant, and then wonder if that means they're depressed. It doesn't, not by itself.
Anxiety Disorders are characterized by a sense of doubt and vulnerability about future events. The attention of anxious people is focused on their future prospects, and the fear that those future prospects will be bad. Anxiety Disorders are characterized by a variety of symptoms involving anxious thoughts, unexplained physical sensations, and avoidant or self protective behaviors.

Medical problems. Dealing with a serious health problem, such as stroke, heart attack, or cancer, can lead to depression. Research shows that people who have a serious illness and depression are more likely to have more serious types of both conditions.4 Some medical illnesses, like Parkinson’s disease, hypothyroidism, and stroke, can cause changes in the brain that can trigger depression.
The new world of pharmacogenetics holds the promise of actually keeping the genes responsible for depression turned off so as to avoid the illnesses completely. Also, by studying genes, we are learning more about the matching of patients with treatment. This kind of information can tell us which patients do well on which types of drugs and psychotherapy regimens.

While some people describe depression as “living in a black hole” or having a feeling of impending doom, others feel lifeless, empty, and apathetic. Men in particular can feel angry and restless. No matter how you experience depression, left untreated it can become a serious health condition. But it’s important to remember that feelings of helplessness and hopelessness are symptoms of depression—not the reality of your situation. There are plenty of powerful self-help steps you can take to lift your mood, overcome depression, and regain your joy of life.
People living with high-functioning anxiety and depression may appear fine, but they are far from being as emotionally and mentally healthy as they could be. Seeking treatment is an important step to improving overall emotional and mental health to its potential level. High-functioning anxiety and depression is very treatable, but often the difficulty is in identifying the signs and symptoms and realizing there is a problem.

One reason depression is difficult to identify is that its symptoms can vary depending on age and sex. Adults with depression generally feel overwhelmed by sadness, while depression in adolescents tends to express itself mainly as irritability. Women with depression are more likely to note symptoms like anxiety and indecisiveness, while men are more likely to report anger and aggression.
Your GP will have suggestions for alternative things you can try to help manage your depression from day to day, and will be able to assess if you need medication or further help. Treatments such as cognitive behavioural therapy and medication, and having a good relationship with a GP, psychologist and/or psychiatrist, can be effective in treating depression and improving mood.
Behavioral therapies for depression require a commitment to changing behaviors that make depression worse. They often focus on getting involved in enjoyable or rewarding activities, knowing that if you force yourself to do these things your mood will improve over time. Changing thoughts about certain aspects of life can also be useful. Behavioral interventions for anxiety include safe and gradual exposure to the things that the patient fears. It too involves changing how the patient thinks about those things. Behavioral therapies are effective for depression, and tend to be more effective than medication for anxiety disorders, particularly for long-term relief. For many patients, combining medication and behavioral therapy is better than either one alone for depression, anxiety, and headache.
For treatment with antidepressants to work, a careful diagnosis has to be made first. Experts believe that some people are prescribed antidepressants unnecessarily. The fact that significantly more people take antidepressants nowadays suggests that. These medications are sometimes already prescribed for milder cases, even though there is doubt about how well they work in mild depression.
We know it can be tough take on any of these depression self help tips when you’re feeling really bad. Also, when it comes to self-help, strategies for feeling better are very individualistic. That is, different things work for different people. Not everyone will want to start doing yoga, for example, so keep trying different ideas even if the first thing you try doesn’t help.
Perimenopause, which is the time of life immediately before and after menopause, can last as long as 10 years. While perimenopause and menopause are normal stages of life, perimenopause increases the risk of depression during that time. Also, women who have had depression in the past are five times more likely to develop major depression during perimenopause.
More than 1in 6 Americans take a psychiatric drug (such as an antidepressant or a sedative). according to a 2013 Medical Expenditure Panel Survey (MEPS), which gathered information on the cost and use of health care in the United States. Antidepressants were the most common type of psychiatric drug in the survey, with 12 percent of adults reporting that they filled prescriptions for these drugs, the study said.
Clinical depression goes by many names, such as “the blues,” biological or clinical depression, and a major depressive episode. But all of these names refer to the same thing: feeling sad and depressed for weeks or months on end — not just a passing blue mood of a day or two. This feeling is most often accompanied by a sense of hopelessness, a lack of energy (or feeling “weighed down”), and taking little or no pleasure in things that once gave a person joy in the past.
Selective serotonin reuptake inhibitors or SSRIs are the most widely used class of antidepressants. They work by increasing the level of serotonin in the brain. Unlike MAOIs and TCAs, SSRIs do not significantly affect norepinephrine levels in the brain. SSRIs also have fewer and milder side effects, fewer drug interactions, and are much less likely to be associated with suicide than TCAs.
As the name implies, antidepressants are used for the treatment of depression. It is now clear that in addition to improving one’s mood, antidepressants also have an anti-anxiety effect. Antidepressants are believed to affect certain (chemical messengers) in the brain, resulting ​in a better mood and less anxiety. Today, antidepressants are the usual choice of medication intervention for major depressive disorders and anxiety disorders.
The next time you're feeling terrible about yourself, use logic as a natural depression treatment. You might feel like no one likes you, but is there real evidence for that? You might feel like the most worthless person on the planet, but is that really likely? It takes practice, but in time you can beat back those negative thoughts before they get out of control.
Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. Also called major depressive disorder or clinical depression, it affects how you feel, think and behave and can lead to a variety of emotional and physical problems. You may have trouble doing normal day-to-day activities, and sometimes you may feel as if life isn't worth living.
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