不负责任的说,根据我自己和见过抑郁患者来看,抑郁的人一般都是比较较真,对自己苛刻,对别人善良,敏感。抑郁的原因有遗传,有失恋,家里出事,学业工作人际关系等等等等上面的人已经说的很清楚了。从表现上看抑郁和普通的低潮最大的区别就是不可控制自己的情绪。而精神上最大的区别在于和常人产生厌世厌人低落情绪不同,抑郁症患者在这些背后往往都有一个他终极最讨厌的人,那就是他自己。在他们诸多觉得没意思,讨厌,肮脏的事物中,他们最为憎恨自己。我知道这个世界上对自己很满意的人不多,但是正常人不会真正特别责怪自己,厌恶自己,划伤自己,自残自杀。抑郁症患者的厌世里面绝对包含着一个自己。他们可能很多认识到这样的憎恨自己不对,然后认为自己怎么会做憎恨自己这种不对的事情呢,不能好好说话像那些好人坚强的人一样好好活着嘛? 而更加憎恨自己。这也是抑郁的一个典型恶性循环。不负责任的说抑郁症患者大都试图改变自己的这种状态,有的人成功了,有的人暂时失败着,有的人就彻底失败了,举个例子张国荣。抑郁的人一方面觉得自己真的无能为力,是自己在抑郁做不到,需要别人理解,一方面又会责怪自己:开什么玩笑,别人断胳膊少腿都没有抑郁你他娘的抑郁什么什么做不到。。。绝对不是抑郁,就是个懦夫,懒惰,胆小鬼,没能力。然后久了就会觉得像我这种没事还抑郁什么xx玩意的废柴,有什么资格活在世界上,看看人家。我说过,抑郁的人一般真的很较真。


第二,加强营养。良好的饮食结构可以使我们身体机能得到很大的提高,抑郁症患者在日常治疗过程中,除了按时吃药以外日常饮食也是非常需要注意的,有些食物对改善抑郁有较大的益处。如深海瑰宝——鱼。鱼体内的成分Omega-3脂肪酸是天然的抵抗抑郁症的瑰宝。常食用海鱼,会明显降低抑郁症的发病、缓解抑郁情绪。还有快乐水果——香蕉、葡萄柚、樱桃等,其中,香蕉有一种可以令人兴奋和提高情绪精神的物质——生物碱,非常有利于增加人体大脑血清素。血清素的增加有助于,神经细胞的传递,提高大脑神经系统,这也是抑郁症的食疗方法之一。心情法宝——大蒜、南瓜。大蒜和南瓜都是帮助人们恢复心情的法宝。常吃大蒜人们就不会感觉劳累和焦虑,对急躁情绪有所缓解。南瓜中的维生素可以帮助人体补充B6和铁,南瓜被称为天然的人体汽油。合理的饮食对人体本身产生积极因素,都是对抗抑郁的好东西,但是我们还是要注意有些食物不适合患者,如酒、浓茶、咖啡、油炸辛辣等食物,尽可能避免食用。
我大概是去年12月的时候,也就是2015年12月,确诊的焦虑症。不过,确诊的过程有些曲折和漫长。跟很多得过类似疾病的人一样,我也是走了很多弯路才最终确诊的。确诊之后,为了寻找病因,我仔细回忆过,发现自己大概从2014年下半年就开始出现轻微的症状了。只是那时候根本没想过会发展到这么严重的地步。一开始,我只是时常觉得头晕,鼻子不通气(我有比较严重的过敏性鼻炎),常常容易紧张(那时候准备毕业,去面试的时候总会过度紧张),常常无法集中精神,脱发也比较严重(每次洗头,手上总是满满的头发,洗一次头起码掉一百多根),经常觉得乏力,想睡觉。出现这些症状前,我曾经因为烟酒过多得过一次挺严重的急性肺炎和支气管炎。打了差不多十瓶急先锋之后,休息了七八个月才逐步恢复。但是明显能感觉到自己的体质下降了很多。于是,那段时间老是怀疑自己身体有毛病,怀疑最多的是两个,癌症(抽烟)和肾虚(脱发,乏力)。
BACKGROUND: In 2001, the Canadian Psychiatric Association and the Canadian Network for Mood and Anxiety Treatments (CANMAT) partnered to produce evidence-based clinical guidelines for the treatment of depressive disorders. A revision of these guidelines was undertaken by CANMAT in 2008-2009 to reflect advances in the field. There is renewed interest in refined approaches to brain stimulation, particularly for treatment resistant major depressive disorder (MDD). METHODS: The CANMAT guidelines are based on a question-answer format to enhance accessibility to clinicians. An evidence-based format was used with updated systematic reviews of the literature and recommendations were graded according to Level of Evidence using pre-defined criteria. Lines of Treatment were identified based on criteria that included evidence and expert clinical support. This section on "Neurostimulation Therapies" is one of 5 guidelines articles. RESULTS: Among the four forms of neurostimulation reviewed in this section, electroconvulsive therapy (ECT) has the most extensive evidence, spanning seven decades. Repetitive transcranial magnetic (rTMS) and vagus nerve stimulation (VNS) have been approved to treat depressed adults in both Canada and the United States with a much smaller evidence base. There is also emerging evidence that deep brain stimulation (DBS) is effective for otherwise treatment resistant depression, but this is an investigational approach in 2009. LIMITATIONS: Compared to other modalities for the treatment of MDD, the data based is limited by the relatively small numbers of randomized controlled trials (RCTs) and small sample sizes. CONCLUSIONS: There is most evidence to support ECT as a first-line treatment under specific circumstances and rTMS as a second-line treatment. Evidence to support VNS is less robust and DBS remains an investigational treatment.
And one of the things that often gets lost in discussions of depression is that you know it's ridiculous. You know it's ridiculous while you're experiencing it. You know that most people manage to listen to their messages and eat lunch and organize themselves to take a shower and go out the front door and that it's not a big deal, and yet you are nonetheless in its grip and you are unable to figure out any way around it. And so I began to feel myself doing less and thinking less and feeling less. It was a kind of nullity.

But in 1994, three years later, I found myself losing interest in almost everything. I didn't want to do any of the things I had previously wanted to do, and I didn't know why. The opposite of depression is not happiness, but vitality. And it was vitality that seemed to seep away from me in that moment. Everything there was to do seemed like too much work. I would come home and I would see the red light flashing on my answering machine, and instead of being thrilled to hear from my friends, I would think, "What a lot of people that is to have to call back." Or I would decide I should have lunch, and then I would think, but I'd have to get the food out and put it on a plate and cut it up and chew it and swallow it, and it felt to me like the Stations of the Cross.
And then the anxiety set in. If you told me that I'd have to be depressed for the next month, I would say, "As long I know it'll be over in November, I can do it." But if you said to me, "You have to have acute anxiety for the next month," I would rather slit my wrist than go through it. It was the feeling all the time like that feeling you have if you're walking and you slip or trip and the ground is rushing up at you, but instead of lasting half a second, the way that does, it lasted for six months. It's a sensation of being afraid all the time but not even knowing what it is that you're afraid of. And it was at that point that I began to think that it was just too painful to be alive, and that the only reason not to kill oneself was so as not to hurt other people.
目的观察抑郁大鼠电休克治疗后海马内谷氨酸含量以及N-甲基-D天门冬氨酸(NMDA)受体 的表达,探讨电休克治疗抑郁症的谷氨酸能神经机制。方法36只SD大鼠随机分为无抽搐电休克组(电休克组)、抑郁模型对照组(抑郁组)、对照组,每组12 只。前两组采用孤养加慢性不可预见性应激建立抑郁模型,建模后电休克组在丙泊酚麻醉下行无抽搐电休克治疗,隔天1次共2周。检测各组海马谷氨酸含量和海马 CA1区、CA3区NMDA受体2B亚单位(NMDA-NP,2B)的表达。结果①电休克治疗后电休克组大鼠水平移动格数、垂直竖立次数和糖水消耗量都高 于抑郁组(P〈0.01)。②电休克组大鼠海马内谷氨酸含量低于抑郁组(P〈0.01),而抑郁组高于正常组(P〈0.01)。③电休克组大鼠海马CAI 区和CA3区NMDA.NP,2B的表达量高于正常组(P〈0.05),而抑郁组低于正常组(P〈0.01)。结论无抽搐电休克治疗可抑制抑郁症模型大鼠 海马内谷氨酸含量的升高并使NMDA—NR2B的表达量上调,这可能是其抗抑郁机制之一。
Manic-depressive or bipolar depression is not as common as other forms of depression. Bipolar disorder used to be known as ‘manic depression’ because in this the person experiences periods of mania and periods of depression, with periods of normal mood in between. About 1% of the population will experience bipolar disorder at some time in their lives. In bipolar disorder cycles of mood swings from mania to depression occur over time. The mood change may have a psychotic basis with delusional thinking or occur in isolation and induce anxiety.
But in 1994, three years later, I found myself losing interest in almost everything. I didn't want to do any of the things I had previously wanted to do, and I didn't know why. The opposite of depression is not happiness, but vitality. And it was vitality that seemed to seep away from me in that moment. Everything there was to do seemed like too much work. I would come home and I would see the red light flashing on my answering machine, and instead of being thrilled to hear from my friends, I would think, "What a lot of people that is to have to call back." Or I would decide I should have lunch, and then I would think, but I'd have to get the food out and put it on a plate and cut it up and chew it and swallow it, and it felt to me like the Stations of the Cross.
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