As clinicians, we routinely make critical decisions for our patients with depression. Because of the uncertainty of factors that affect diagnosis and treatment, clinicians may find an objective, quick measurement tool helpful. Measurementbased care (MBC) provides specific and objective information on which to base clinical decisions and should therefore enhance quality of care and treatment outcomes. (1-3) MBC rests on these assumptions. * Compared with general questions that are typically asked during a patient evaluation, specific measurements (administered by clinicians or self-reported by patients) provide more accurate information on which to establish a diagnosis, assess treatment outcomes, and modify treatments. * Patients who complete these measurement tests will better understand their disorder and treatment effects, which will enable them to better manage their depression. * Medical records that include the results of specific measurements will assist subsequent clinicians in understanding the results of prior treatments. * The routine use of the same measurements in practice and clinical research studies will help clinicians translate research findings into their own practices. * For most outpatients with depression, self-report methods are available that are free and that take little time and effort. Diagnostic measurements Researchers have used criterion-based diagnostic methods for years. After DSM-III was introduced in 1980, the Structured Clinical Interviews for DSM-III (SCID) (and later for DSMIV) were developed to obtain lifetime diagnoses. (4,5) Briefer structured interviews were then developed, including the Mini-International Neuropsychiatric Interview (MINI), which assesses only current diagnoses, and the MINI-Plus, which elicits information about current and past diagnoses. (6-8) The MINI takes 30 to 40 minutes to administer, while the MINI-Plus may take up to 60 minutes. Studies have shown that structured or semistructured interviews provide more accurate diagnoses than typical practice. For example, clinically rendered diagnoses were compared with those made based on SCID results. (9) Major diagnostic differences were found in 40% of outpatients with clinical diagnoses of schizophrenia or bipolar or major depressive disorders. In addition, when clinicians were provided with a diagnosis that was determined using SCID, they changed the chart diagnosis in a substantial proportion of cases and prescribed fewer medications. (10) Symptom measurements Once a diagnosis has been made and therapy has been initiated, the regimen must often be modified because of intolerance, adverse effects, or other less-than-desirable symptomatic outcomes. Medication and somatic therapies are typically aimed at treating symptoms, but psychotherapy and disease self-management may also address other aspects of treatment (eg, medication adherence, social/occupational function, self-esteem). The Texas Medication Algorithm Project (TMAP) and the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) studies showed that diligent assessment of symptoms and adverse effects enhances outcomes. (11-14) The goal of therapy for depression is symptom remission and, ultimately, sustained remission and functional recovery. (15) Most patients require more than 1 treatment revision (eg, altered dosage, treatment, or delivery). When implementing guideline-driven or evidencebased care, initial treatment is continued until remission or maximal symptom improvement is obtained or until the patient cannot tolerate the regimen. Thereafter, the dosage or type of treatment may...
由于不了解你女朋友的具体情况,我不好给出意见。从你的另外一个帖子里,我能够感到你对她的关心、你的焦急,但是我也想提醒你,想要关心抑郁症患者的家属,首先要学会关心自己。一个人可以轻易学会不在乎,但学会在乎,却需要付出千百倍的勇气和努力。我的女朋友在陪伴我的时候,自己也经历了不少痛苦。她后来通过咨询心理医生应该怎么照顾我,来调整好了自己的情绪。我想告诉你的是,你要对抑郁症有所准备(教育自己,学习一些这方面的知识),即使你是一个很乐观和活泼的人。陪伴抑郁症患者很消耗人的能量。我给你推荐两个专业团队的回答。 这个问题中 ID为“简单心理”的回答,这里面你可以读到一些故事(有些故事比较恐怖,你不必被吓到,结合你自己的情况考虑,你女友未必那么严重);Knowyourself这个团队写的 “因为爱你,我想陪着你不快乐|研究:抑郁会在伴侣间传染” 。你能来问这个问题,说明你充满了爱心,我为你点赞!祝你女友能走出这段阴霾。

A revision of the 2008 British Association for Psychopharmacology evidence-based guidelines for treating depressive disorders with antidepressants was undertaken in order to incorporate new evidence and to update the recommendations where appropriate. A consensus meeting involving experts in depressive disorders and their management was held in September 2012. Key areas in treating depression were reviewed and the strength of evidence and clinical implications were considered. The guidelines were then revised after extensive feedback from participants and interested parties. A literature review is provided which identifies the quality of evidence upon which the recommendations are made. These guidelines cover the nature and detection of depressive disorders, acute treatment with antidepressant drugs, choice of drug versus alternative treatment, practical issues in prescribing and management, next-step treatment, relapse prevention, treatment of relapse and stopping treatment. Significant changes since the last guidelines were published in 2008 include the availability of new antidepressant treatment options, improved evidence supporting certain augmentation strategies (drug and non-drug), management of potential long-term side effects, updated guidance for prescribing in elderly and adolescent populations and updated guidance for optimal prescribing. Suggestions for future research priorities are also made.

总的来说,同一类别的抗抑郁药物对大部分抑郁症患者的药效是相似的。在住院的患者中,阿米替林_百度百科或者氯丙咪嗪_百度百科的效果可能会比SSRIs和TCAs类药物略好一点。而更老的MAOIs效果则比丙咪嗪_百度百科 更弱。而文拉法辛_百度百科 ,西酞普兰_百度百科, 盐酸舍曲林片_百度百科的效果相较于其他的集中SSRIs药物而言略微更为有效。对于西酞普兰_百度百科来说,20mg可以为重度抑郁症患者产生显著疗效的剂量。也有部分研究发现米氮平_百度百科 的效果略比其他更新一型的抗抑郁药物好。对于季节性抑郁症,相关研究较少,不过大部分都以SSRIs为治疗药物。另外,共病也是选药的因素之一,比如有研究发现在同时患有强迫症的抑郁症患者中,盐酸舍曲林片_百度百科的效果比地昔帕明_百度百科的效果要好。而对持续性的抑郁症,也有研究发现吗氯贝胺_百度百科 和阿米舒必利_百度百科 的效果比氟西汀_百度百科 要好。从总的药物效果来说,有非常充足的证据证明SSRIs类药物的药效比安慰剂要好的多,量表数据表明患者接受药物治疗可以减少50%以上的症状减轻并且有部分研究发现药物可以增加康复的的速率。