This practice parameter describes the epidemiology, clinical picture, differential diagnosis, course, risk factors, and pharmacological and psychotherapy treatments of children and adolescents with major depressive or dysthymic disorders. Side effects of the antidepressants, particularly the risk of suicidal ideation and behaviors are discussed. Recommendations regarding the assessment and the acute, continuation, and maintenance treatment of these disorders are based on the existent scientific evidence as well as the current clinical practice.
And then the anxiety set in. If you told me that I'd have to be depressed for the next month, I would say, "As long I know it'll be over in November, I can do it." But if you said to me, "You have to have acute anxiety for the next month," I would rather slit my wrist than go through it. It was the feeling all the time like that feeling you have if you're walking and you slip or trip and the ground is rushing up at you, but instead of lasting half a second, the way that does, it lasted for six months. It's a sensation of being afraid all the time but not even knowing what it is that you're afraid of. And it was at that point that I began to think that it was just too painful to be alive, and that the only reason not to kill oneself was so as not to hurt other people. 

不负责任的说,根据我自己和见过抑郁患者来看,抑郁的人一般都是比较较真,对自己苛刻,对别人善良,敏感。抑郁的原因有遗传,有失恋,家里出事,学业工作人际关系等等等等上面的人已经说的很清楚了。从表现上看抑郁和普通的低潮最大的区别就是不可控制自己的情绪。而精神上最大的区别在于和常人产生厌世厌人低落情绪不同,抑郁症患者在这些背后往往都有一个他终极最讨厌的人,那就是他自己。在他们诸多觉得没意思,讨厌,肮脏的事物中,他们最为憎恨自己。我知道这个世界上对自己很满意的人不多,但是正常人不会真正特别责怪自己,厌恶自己,划伤自己,自残自杀。抑郁症患者的厌世里面绝对包含着一个自己。他们可能很多认识到这样的憎恨自己不对,然后认为自己怎么会做憎恨自己这种不对的事情呢,不能好好说话像那些好人坚强的人一样好好活着嘛? 而更加憎恨自己。这也是抑郁的一个典型恶性循环。不负责任的说抑郁症患者大都试图改变自己的这种状态,有的人成功了,有的人暂时失败着,有的人就彻底失败了,举个例子张国荣。抑郁的人一方面觉得自己真的无能为力,是自己在抑郁做不到,需要别人理解,一方面又会责怪自己:开什么玩笑,别人断胳膊少腿都没有抑郁你他娘的抑郁什么什么做不到。。。绝对不是抑郁,就是个懦夫,懒惰,胆小鬼,没能力。然后久了就会觉得像我这种没事还抑郁什么xx玩意的废柴,有什么资格活在世界上,看看人家。我说过,抑郁的人一般真的很较真。
虽然药物和心理方面的干预措施对重度抑郁患者均有效,但抗抑郁药物仍是治疗重度抑郁症的主要手段。在过去二十年里,SSRIs(5−羟色胺再摄取抑制剂)已逐步成为最常用的抗抑郁处方药。Escitalopram作为最新上市的一类SSRI药物,是外旋西酞普兰的纯S-对映异构体。在本系统评价中,我们对Escitalopram与其他抗抑郁药相比治疗急性期重度抑郁症的有效性、可接受性和耐受性进行了评价。共有22个随机对照试验(约4000名受试者)纳入本研究。结果显示: Escitalopram似乎适合成为治疗中到重度抑郁症的一线药物。由于纳入研究只比较了少数几种抗抑郁药物,因此我们无法确定其疗效与其他众多临床抗抑郁剂相比,孰好孰坏。不过可以确定的是,对6个研究(接近2000名病人)的合并结果表明,Escitalopram的疗效优于citalopram。
Abstract DESCRIPTION: Update of the 2009 U.S. Preventive Services Task Force (USPSTF) recommendation on screening for major depressive disorder (MDD) in children and adolescents. METHODS: The USPSTF reviewed the evidence on the benefits and harms of screening; the accuracy of primary care-feasible screening tests; and the benefits and harms of treatment with psychotherapy, medications, and collaborative care models in patients aged 7 to 18 years. POPULATION: This recommendation applies to children and adolescents aged 18 years or younger who do not have a diagnosis of MDD. RECOMMENDATION: The USPSTF recommends screening for MDD in adolescents aged 12 to 18 years. Screening should be implemented with adequate systems in place to ensure accurate diagnosis, effective treatment, and appropriate follow-up. (B recommendation) The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for MDD in children aged 11 years or younger. (I statement).
This practice parameter describes the epidemiology, clinical picture, differential diagnosis, course, risk factors, and pharmacological and psychotherapy treatments of children and adolescents with major depressive or dysthymic disorders. Side effects of the antidepressants, particularly the risk of suicidal ideation and behaviors are discussed. Recommendations regarding the assessment and the acute, continuation, and maintenance treatment of these disorders are based on the existent scientific evidence as well as the current clinical practice.

虽然药物和心理方面的干预措施对重度抑郁患者均有效,但抗抑郁药物仍是治疗重度抑郁症的主要手段。在过去二十年里,SSRIs(5−羟色胺再摄取抑制剂)已逐步成为最常用的抗抑郁处方药。Escitalopram作为最新上市的一类SSRI药物,是外旋西酞普兰的纯S-对映异构体。在本系统评价中,我们对Escitalopram与其他抗抑郁药相比治疗急性期重度抑郁症的有效性、可接受性和耐受性进行了评价。共有22个随机对照试验(约4000名受试者)纳入本研究。结果显示: Escitalopram似乎适合成为治疗中到重度抑郁症的一线药物。由于纳入研究只比较了少数几种抗抑郁药物,因此我们无法确定其疗效与其他众多临床抗抑郁剂相比,孰好孰坏。不过可以确定的是,对6个研究(接近2000名病人)的合并结果表明,Escitalopram的疗效优于citalopram。
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