Abstract BACKGROUND: Prefrontal Transcranial Magnetic Stimulation (TMS) therapy repeated daily over 4-6 weeks (20-30 sessions) is US Food and Drug Administration (FDA) approved for treating Major Depressive Disorder in adults who have not responded to prior antidepressant medications. In 2011, leading TMS clinical providers and researchers created the Clinical TMS Society (cTMSs) (www.clinicaltmssociety.org, Greenwich, CT, USA), incorporated in 2013. METHODS: This consensus review was written by cTMSs leaders, informed by membership polls, and approved by the governing board. It summarizes current evidence for the safety and efficacy of the use of TMS therapy for treating depression in routine clinical practice. Authors systematically reviewed the published TMS antidepressant therapy clinical trials. Studies were then assessed and graded on their strength of evidence using the Levels of Evidence framework published by the University of Oxford Centre for Evidence Based Medicine. The authors then summarize essentials for using TMS therapy in routine clinical practice settings derived from discussions and polls of cTMSs members. Finally, each summary clinical recommendation is presented with the substantiating peer-reviewed, published evidence supporting that recommendation. When the current published clinical trial evidence was insufficient or incomplete, expert opinion was included when sufficient consensus was available from experienced clinician users among the membership of the cTMSs, who were polled at the Annual Meetings in 2014 and 2015. CONCLUSIONS: Daily left prefrontal TMS has substantial evidence of efficacy and safety for treating the acute phase of depression in patients who are treatment resistant or intolerant. Following the clinical recommendations in this document should result in continued safe and effective use of this exciting new treatment modality. Copyright 脗漏 2016 The Authors. Published by Elsevier Inc. All rights reserved.能坐得久一点。站着的时候必须找东西靠着,有时候靠墙上,有时候靠着桌子,否则就会开始烦躁不安,感觉自己马上就会晕过去或者突然猝死一样。另外,我还特别怕吵闹,如果身边的人说话稍微大声一些,就会觉得很烦躁,很想逃离出去。感觉所有的噪声在拼命地往我脑子里钻。那段时间我非常抵触跟别人交谈,不必要的社交也都尽可能推掉,甚至上司请吃饭我都不想去。我开始越来越少说话,因为说多了会累,气接不上(这再次让我怀疑我肾虚)。因此,一整天,如非必要,我绝不开口说话。对于刚换了新工作的我来说,这等于是将自己与所有同事都隔绝开了。因此,每天一上班,我就觉得周围的气氛异常的压抑,大家都很陌生,即使我已经在那里上班超过两个月了,可是,依然无法跟身边的同事好好交流。上班成了一件非常痛苦的事情。
And then the anxiety set in. If you told me that I'd have to be depressed for the next month, I would say, "As long I know it'll be over in November, I can do it." But if you said to me, "You have to have acute anxiety for the next month," I would rather slit my wrist than go through it. It was the feeling all the time like that feeling you have if you're walking and you slip or trip and the ground is rushing up at you, but instead of lasting half a second, the way that does, it lasted for six months. It's a sensation of being afraid all the time but not even knowing what it is that you're afraid of. And it was at that point that I began to think that it was just too painful to be alive, and that the only reason not to kill oneself was so as not to hurt other people.
得知我得的是焦虑症之后,我开始回忆自己这差不多两年来的种种表现。我发现,过去的两年来,只有24岁的我,活得像一个七八十岁的老人。我抗拒社交,总是无精打采,全身乏力,从一楼走到4楼中途都要停下来休息一下,说话说多一些就上气不接下气,站几分钟就得找地方靠着。买一堆党参枸杞红枣,甚至当归来泡水喝,一天不喝就觉得自己会突然晕过去。晚上入睡之前,身体总会不停地震颤。半夜会突然胸闷惊醒,就像被谁捂着鼻子和嘴巴透不过气来一样。那段时间,我一直在担心自己会突然死掉。我常常回想自己二十几年的人生,到底做了些什么?常常想起自己以前做错的事情,然后心情会突然跌入低谷,每天下班,或者周末休息的时候,我都是一个人关在房间里坐在书桌前发呆,或者看书。一整天几乎都不说话。我开始失去食欲,肚子饿了也不想吃东西。吃饭吃到一半会突然胸闷。

ECT亦称电抽搐治疗,拟短时间内适量电流通过患者头部致全身抽搐,而达到治疗疾病目的的一种有效疗法。自1930年问世,ECT拟人工诱导癫痫发作的方法来改善精神分裂症的症状,却在治疗实践中被发现对抑郁症状有明显改善作用。随着技术的发展与成熟,近年来又出现附加简单麻醉和应用肌肉松弛剂的改良ECT(无抽搐ECT),使得治疗更为安全和可接受。ECT具有起效快、效果好等优点,多个临床治疗指南推荐其作为严重抑郁症紧急情况下(如高危自杀风险、极度痛苦、流体摄入不足)的治疗首选[8-9,12-14]。需注意,ECT可能存在一定的脑血管意外、认知功能损害等风险,故治疗前应充分评估风险收益,且治疗后应继续进行抗抑郁症药物治疗,以降低复发风险。ECT治疗抑郁症机制仍待进一步研究,其机制可能涉及激活GABA通路、突触重塑、减少谷氨酸、上调NMDA-NR2B表达等[21]。
抑郁症的诊断主要根据WHO制定的《疾病和有关健康问题的国际统计分类》第10次修订本(International Classification of Diseases,ICD-10)[6]及美国精神病学会(American Psychiatric Association,APA)制定的《精神疾病的诊断和统计手册》第5次修订本(Diagnostic and Statistical Manual of Mental Disorders-5,DSM-5)[7]标准。抑郁症诊断的核心标准为抑郁发作持续至少2周,既往不存在轻躁狂或躁狂发作且除外精神活性物质或器质性精神障碍。目前抑郁症的诊断仍主要基于临床症状主诉,尚无特异性较好的实验室及辅助检查确诊方法。ICD-10及DSM-5中抑郁症的诊断标准主要包括[6-7]:①相对固定的不合乎个体实际情况的抑郁心境,且存在于一天中大多数时间,持续至少2周;②对平时感兴趣的事情丧失兴趣或愉快感;③常感疲惫,精力不足;④其他:自信心丧失、自卑、无价值感、无理由的过分自责、不适当的罪恶感、失眠、食欲减退、体质量减轻、思维分散、注意力降低、反复出现自杀观念或自杀行为等。根据符合的症状条款数目,ICD-10和DSM-5分别界定抑郁的轻、中、重严重程度。英国国家临床最优化研究所(National Institute for Health and Care Excellence,NICE)首次提出阈下抑郁这一新亚型[8],系指低于轻度抑郁症诊断标准,以长期存在1或2项抑郁症状为主要特征,如失眠、疲惫、注意力分散、效率下降、躯体不适等,临床常易忽视。NICE指出,阈下抑郁在英国的患病率高,为30%~40%,与抑郁症造成同样严重的自残、自杀影响及经济损失,值得重视。

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我大概是去年12月的时候,也就是2015年12月,确诊的焦虑症。不过,确诊的过程有些曲折和漫长。跟很多得过类似疾病的人一样,我也是走了很多弯路才最终确诊的。确诊之后,为了寻找病因,我仔细回忆过,发现自己大概从2014年下半年就开始出现轻微的症状了。只是那时候根本没想过会发展到这么严重的地步。一开始,我只是时常觉得头晕,鼻子不通气(我有比较严重的过敏性鼻炎),常常容易紧张(那时候准备毕业,去面试的时候总会过度紧张),常常无法集中精神,脱发也比较严重(每次洗头,手上总是满满的头发,洗一次头起码掉一百多根),经常觉得乏力,想睡觉。出现这些症状前,我曾经因为烟酒过多得过一次挺严重的急性肺炎和支气管炎。打了差不多十瓶急先锋之后,休息了七八个月才逐步恢复。但是明显能感觉到自己的体质下降了很多。于是,那段时间老是怀疑自己身体有毛病,怀疑最多的是两个,癌症(抽烟)和肾虚(脱发,乏力)。
Brintellix通用名Vortioxetine,是一种调节和促进血清素分泌类的药物,属于非典型性抗抑郁症药物,它的机制目前还不完全清楚,但是发现它同时起到血清素再摄取抑制剂、去甲肾上腺素再摄取抑制剂、5-HT 1A受体激动剂、5-HT 1B受体部分激动剂等功能。武田制药声称,这款药物是目前唯一通过这种综合性的功能来促进血清素水平的药物,虽然每一种功能对其发挥抗抑郁作用的贡献有多大,目前为止还不是很清楚,此药除了能够改善患者的情绪外,临床研究显示还能改善认知功能,对于目前市场上销售的抗抑郁症药物来说,这可以称得上是一种具有进步性的药物。此药由武田和丹麦的灵北制药公司共同销售,在这笔交易中武田支付灵北制药4000万美元的先期付款,另外总计高达3.45亿美元的里程碑付款。2013年先后在美国和欧盟上市,预测2017年销售额8.45亿美元, 2021年销售额为17.5亿美元。
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